Human Stem Cells Generate Multi-Zonal Liver Organoids
Journal: Nature
Author: Hasan Al Reza et. al, USA
Scientists created liver organoids with distinct zones by combining ascorbate/bilirubin-enriched cells. These organoids show zone-specific functions, reveal hepatocyte differentiation paths, and improved survival in rats with liver disease.
Blood Vessel Organoids Map Vascular Development
Journal: Cell
Author: Marina T. Nikolova et. al, Switzerland
Researchers used multi-omics to track blood vessel organoid development, identifying endothelial-mural cell fate bifurcation and key regulators. LEF1 overexpression increased brain vasculature specificity, offering insights for disease modeling.
Mitochondrial Positioning Critical for Stem Cell Reprogramming
Journal: Stem Cell Reports, ISSCR
Author: Ge Xiang et. al, China
OCT4-regulated mitochondrial clustering around the nucleus is essential for mesenchymal-to-epithelial transition during pluripotency induction. This process depends on dynein-mediated transport and affects β-catenin/E-cadherin stability.
Zebrafish Heart Atlas Reveals Regeneration Secrets
Journal: Nature Communications
Author: Lei Li et. al, China
An integrated spatial transcriptomics atlas of regenerating zebrafish heart identified unique cardiomyocyte states and potential regeneration genes. The 4D “virtual heart” comprising 569,896 cells offers insights into vertebrate heart repair.
