Construction organoid model of ovarian endometriosis and the function of estrogen and progesterone in the model
Journal: Scientific Reports
Author: Ruiqi Zhang et al., China
The study established organoid models of eutopic and ectopic endometrial epithelial cells from ovarian endometriosis patients. These organoids preserved original tissue structure and genetic composition, and showed different responses to estrogen and progesterone concentrations.
Wnt signaling modulates mechanotransduction in the epidermis to drive hair follicle regeneration
Journal: Science Advances
Author: Allen S. W. Oak et al., USA
Scientists find Wnt signaling’s role in regulating tissue mechanics for hair regeneration. It reduces nuclear rigidity and attenuates substrate rigidity response in epidermal cells by reorganising actin and recruiting adherens junctions, creating optimal regenerative conditions.
Deep-tissue transcriptomics and subcellular imaging at high spatial resolution
Journal: Science
Author: Valentina Gandin et al, USA
A new technique called cycleHCR combines DNA barcoding with Hybridization Chain Reaction to achieve highly multiplexed imaging of RNA and proteins, overcoming color channel limitations in fluorescence microscopy for deep tissue analysis.
A Hybrid of an automated multi-filter with a spatial bound particle swarm optimization for Gene selection and cancer classification
Journal: Heliyon
Author: Anas Arram et al., Palestine
The paper proposes AMF-SBPSO, a hybrid gene selection approach for cancer classification that combines automated multi-filters with spatial bound particle swarm optimization to select the most relevant genes from microarray datasets with high accuracy.
