How to Pick Up a Mouse:

Laboratory mice are commonly handled for husbandry and scientific procedures. Traditionally, mice are picked up by the base of the tail, which can compromise their welfare and affect scientific results.

Key Findings:

• Impact of Tail Handling:

• Picking up mice by the tail induces high anxiety and aversion.

• This method negatively affects scientific outcomes, including performance in behavioral tests.

• Benefits of Non-Aversive Methods:

• Using a tunnel or cupped hand significantly reduces anxiety.

• Mice handled with these methods show improved behavioral and physiological responses.

Summary of Research Findings:

• Reduced Anxiety: Mice handled with a tunnel or cupped hand exhibit less anxiety and quickly habituate.
• Efficiency: Non-aversive methods do not add time to husbandry or procedures if staff are adequately trained.
• Reliable Results: Improved behavioral and physiological responses lead to more reliable scientific outcomes.

External Resources:

The North American 3Rs Collaborative offers resources on refined mouse handling, including a high-level overview slide deck for download